{"id":875,"date":"2025-11-07T13:47:33","date_gmt":"2025-11-07T18:47:33","guid":{"rendered":"https:\/\/stutteringresearch.org\/?post_type=research&p=875"},"modified":"2025-11-17T09:11:07","modified_gmt":"2025-11-17T14:11:07","slug":"orpheus-estudo-pesquisa-de-ponta","status":"publish","type":"research","link":"https:\/\/stutteringresearch.org\/pt\/research\/orpheus-study-breakthrough-research\/","title":{"rendered":"Orpheus Study \u2013 Gemlapodect no Tratamento de Adultos com Dist\u00farbio de Flu\u00eancia de In\u00edcio na Inf\u00e2ncia (Gaguez)"},"content":{"rendered":"

Investiga\u00e7\u00e3o inovadora<\/h2>\n
\n

Na reuni\u00e3o da Cimeira do CNS, realizada em Boston esta semana, foram divulgados os resultados do estudo Orpheus numa apresenta\u00e7\u00e3o em p\u00f4ster com o fundador da STARS, Gerald<\/span> A. Maguire MD, como autor principal. O estudo, patrocinado pela Noema Pharma (noemapharma.com), investigou o gemlapodect no tratamento de adultos com Transtorno da Flu\u00eancia com In\u00edcio na Inf\u00e2ncia (Gaguez). O Gemlapodect \u00e9 um medicamento em investiga\u00e7\u00e3o que atua como um inibidor da PDE 10A, que pode modular a hiperatividade da sinaliza\u00e7\u00e3o dopamin\u00e9rgica nas regi\u00f5es estriatais do c\u00e9rebro, postuladas como subjacentes \u00e0 gaguez. O estudo envolveu um novo desenho de aleatoriza\u00e7\u00e3o com resposta ao placebo e utilizou uma escala de classifica\u00e7\u00e3o rec\u00e9m-desenvolvida (a MLGSSS) para avaliar a gravidade da gaguez. Ao remover os sujeitos que mostraram uma resposta inicial ao placebo, o gemlapodect demonstrou um efeito de tratamento significativo em compara\u00e7\u00e3o com o placebo. O Gemlapodect foi, em geral, bem tolerado, com efeitos secund\u00e1rios (relatados como ligeiros a moderados) de seda\u00e7\u00e3o, acatisia (inquieta\u00e7\u00e3o) e distonia (rigidez muscular) superiores ao placebo. Ao contr\u00e1rio de medicamentos que bloqueiam a dopamina previamente estudados na gaguez, n\u00e3o foram observados ganhos de peso.<\/p>\n

Embora o gemlapodect permane\u00e7a em fase de investiga\u00e7\u00e3o e sejam necess\u00e1rias mais pesquisas, este trabalho marca um passo promissor no tratamento da gaguez.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Investiga\u00e7\u00e3o inovadora<\/p>\n

Na reuni\u00e3o da Cimeira do CNS, realizada em Boston esta semana, os resultados do estudo Orpheus foram divulgados numa apresenta\u00e7\u00e3o em poster com o Dr. Gerald A Maguire, fundador da STARS, como autor principal. O estudo, patrocinado pela Noema Pharma (noemapharma.com), investigou a gemlapodect no tratamento de adultos com Dist\u00farbio da Flu\u00eancia de In\u00edcio na Inf\u00e2ncia (Gaguez).<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-875","research","type-research","status-publish","hentry"],"acf":[],"yoast_head":"\nOrpheus Study - Gemlapodect in the Treatment of Adults with Childhood Onset Fluency Disorder (Stuttering) - STARS - Stuttering Treatment and Research Society<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stutteringresearch.org\/pt\/pesquisa\/orpheus-estudo-pesquisa-de-ponta\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Orpheus Study - Gemlapodect in the Treatment of Adults with Childhood Onset Fluency Disorder (Stuttering) - 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