{"id":1428,"date":"2026-03-16T13:20:29","date_gmt":"2026-03-16T17:20:29","guid":{"rendered":"https:\/\/stutteringresearch.org\/?post_type=research&p=1428"},"modified":"2026-03-31T10:30:55","modified_gmt":"2026-03-31T14:30:55","slug":"desregulacao-do-ferro-num-modelo-murino-de-gaguez","status":"publish","type":"research","link":"https:\/\/stutteringresearch.org\/pt\/research\/iron-dysregulation-in-a-mouse-model-of-stuttering\/","title":{"rendered":"Desregula\u00e7\u00e3o do Ferro num Modelo de Rato de Gaguez"},"content":{"rendered":"

\"\"A new preprint study explores whether brain iron levels may play a role in stuttering. Using mice engineered with a stuttering-linked Gnptab<\/em> mutation, the researchers identified significantly increased iron accumulation in the striatum, a brain region critical for motor control.<\/p>\n

The study also found that this excess iron was localized in astrocytes, where it was associated with reduced cell size and complexity. Notably, treatment with an iron-chelating drug improved the animals\u2019 vocalization deficits.<\/p>\n

These findings suggest a novel link between genetic mutations, brain iron dysregulation, and speech-related behavior. The work highlights iron regulation as a promising area for future stuttering research and potential therapeutic development.<\/p>\n

Read the full article here<\/a>.<\/p>\n

Reference:<\/strong>
Millwater M, Bragg C, Bishop D, Adeck A, Karutury RC, Weinhold M, Rao PPN, Zhang R, SheikhBahaei S. Iron dysregulation in mice engineered with a mutation associated with stuttering.<\/em> bioRxiv [Preprint]. 2025 Jul 31:2025.07.30.667752. doi: 10.1101\/2025.07.30.667752.<\/p>\n","protected":false},"excerpt":{"rendered":"

Um novo estudo de pre-print explora se os n\u00edveis de ferro no c\u00e9rebro podem desempenhar um papel na gaguez. Utilizando ratinhos geneticamente modificados com uma muta\u00e7\u00e3o Gnptab associada \u00e0 gaguez, os investigadores identificaram um ac\u00famulo de ferro significativamente aumentado no estriado, uma regi\u00e3o do c\u00e9rebro cr\u00edtica para o controlo motor. O estudo tamb\u00e9m descobriu que este excesso de ferro estava localizado nos astr\u00f3citos, onde estava associado a uma diminui\u00e7\u00e3o do tamanho e da complexidade celular. Notavelmente, o tratamento com um medicamento quelante de ferro melhorou os d\u00e9fices de vocaliza\u00e7\u00e3o dos animais.<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-1428","research","type-research","status-publish","hentry"],"acf":[],"yoast_head":"\nIron Dysregulation in a Mouse Model of Stuttering - STARS - Stuttering Treatment and Research Society<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stutteringresearch.org\/pt\/pesquisa\/desregulacao-do-ferro-num-modelo-murino-de-gaguez\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Iron Dysregulation in a Mouse Model of Stuttering - STARS - Stuttering Treatment and Research Society\" \/>\n<meta property=\"og:description\" content=\"A new preprint study explores whether brain iron levels may play a role in stuttering. 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