{"id":1428,"date":"2026-03-16T13:20:29","date_gmt":"2026-03-16T17:20:29","guid":{"rendered":"https:\/\/stutteringresearch.org\/?post_type=research&p=1428"},"modified":"2026-03-31T10:30:55","modified_gmt":"2026-03-31T14:30:55","slug":"iron-dysregulation-in-a-mouse-model-of-stuttering","status":"publish","type":"research","link":"https:\/\/stutteringresearch.org\/pt\/research\/iron-dysregulation-in-a-mouse-model-of-stuttering\/","title":{"rendered":"Iron Dysregulation in a Mouse Model of Stuttering"},"content":{"rendered":"

\"\"A new preprint study explores whether brain iron levels may play a role in stuttering. Using mice engineered with a stuttering-linked Gnptab<\/em> mutation, the researchers identified significantly increased iron accumulation in the striatum, a brain region critical for motor control.<\/p>\n

The study also found that this excess iron was localized in astrocytes, where it was associated with reduced cell size and complexity. Notably, treatment with an iron-chelating drug improved the animals\u2019 vocalization deficits.<\/p>\n

These findings suggest a novel link between genetic mutations, brain iron dysregulation, and speech-related behavior. The work highlights iron regulation as a promising area for future stuttering research and potential therapeutic development.<\/p>\n

Read the full article here<\/a>.<\/p>\n

Reference:<\/strong>
Millwater M, Bragg C, Bishop D, Adeck A, Karutury RC, Weinhold M, Rao PPN, Zhang R, SheikhBahaei S. Iron dysregulation in mice engineered with a mutation associated with stuttering.<\/em> bioRxiv [Preprint]. 2025 Jul 31:2025.07.30.667752. doi: 10.1101\/2025.07.30.667752.<\/p>\n","protected":false},"excerpt":{"rendered":"

A new preprint study explores whether brain iron levels may play a role in stuttering. Using mice engineered with a stuttering-linked Gnptab mutation, the researchers identified significantly increased iron accumulation in the striatum, a brain region critical for motor control.The study also found that this excess iron was localized in astrocytes, where it was associated with reduced cell size and complexity. Notably, treatment with an iron-chelating drug improved the animals\u2019 vocalization deficits.<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-1428","research","type-research","status-publish","hentry"],"acf":[],"yoast_head":"\nIron Dysregulation in a Mouse Model of Stuttering - STARS - Stuttering Treatment and Research Society<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stutteringresearch.org\/pt\/research\/iron-dysregulation-in-a-mouse-model-of-stuttering\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Iron Dysregulation in a Mouse Model of Stuttering - STARS - Stuttering Treatment and Research Society\" \/>\n<meta property=\"og:description\" content=\"A new preprint study explores whether brain iron levels may play a role in stuttering. 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