{"id":1428,"date":"2026-03-16T13:20:29","date_gmt":"2026-03-16T17:20:29","guid":{"rendered":"https:\/\/stutteringresearch.org\/?post_type=research&p=1428"},"modified":"2026-03-31T10:30:55","modified_gmt":"2026-03-31T14:30:55","slug":"iron-dysregulation-in-a-mouse-model-of-stuttering","status":"publish","type":"research","link":"https:\/\/stutteringresearch.org\/es\/research\/iron-dysregulation-in-a-mouse-model-of-stuttering\/","title":{"rendered":"Desregulaci\u00f3n del Hierro en un Modelo Murino de Tartamudez"},"content":{"rendered":"

\"\"A new preprint study explores whether brain iron levels may play a role in stuttering. Using mice engineered with a stuttering-linked Gnptab<\/em> mutation, the researchers identified significantly increased iron accumulation in the striatum, a brain region critical for motor control.<\/p>\n

The study also found that this excess iron was localized in astrocytes, where it was associated with reduced cell size and complexity. Notably, treatment with an iron-chelating drug improved the animals\u2019 vocalization deficits.<\/p>\n

These findings suggest a novel link between genetic mutations, brain iron dysregulation, and speech-related behavior. The work highlights iron regulation as a promising area for future stuttering research and potential therapeutic development.<\/p>\n

Read the full article here<\/a>.<\/p>\n

Reference:<\/strong>
Millwater M, Bragg C, Bishop D, Adeck A, Karutury RC, Weinhold M, Rao PPN, Zhang R, SheikhBahaei S. Iron dysregulation in mice engineered with a mutation associated with stuttering.<\/em> bioRxiv [Preprint]. 2025 Jul 31:2025.07.30.667752. doi: 10.1101\/2025.07.30.667752.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un nuevo estudio de preimpresi\u00f3n explora si los niveles de hierro en el cerebro podr\u00edan desempe\u00f1ar un papel en la tartamudez. Utilizando ratones modificados gen\u00e9ticamente con una mutaci\u00f3n en Gnptab relacionada con la tartamudez, los investigadores identificaron una acumulaci\u00f3n significativamente mayor de hierro en el estriado, una regi\u00f3n cerebral fundamental para el control motor. El estudio tambi\u00e9n encontr\u00f3 que este exceso de hierro se localizaba en astrocitos, donde se asociaba con una reducci\u00f3n del tama\u00f1o y la complejidad celular. Notablemente, el tratamiento con un f\u00e1rmaco quelante de hierro mejor\u00f3 los d\u00e9ficits de vocalizaci\u00f3n de los animales.<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-1428","research","type-research","status-publish","hentry"],"acf":[],"yoast_head":"\nIron Dysregulation in a Mouse Model of Stuttering - STARS - Stuttering Treatment and Research Society<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stutteringresearch.org\/es\/investigacion\/iron-dysregulation-in-a-mouse-model-of-stuttering\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Iron Dysregulation in a Mouse Model of Stuttering - STARS - Stuttering Treatment and Research Society\" \/>\n<meta property=\"og:description\" content=\"A new preprint study explores whether brain iron levels may play a role in stuttering. 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